Nipah Virus: Understanding the new emerging global threat
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Abstract
Nipah virus, a newly emerged zoonosis, is caused by flying foxes. It has reported occasional outbreaks of encephalitis and respiratory syndrome and a significant mortality rate. Since 1998, when it was first identified in the Malaysia outbreak, this rare brain-damaging virus infection continues to emerge in different parts of the world. Although the risk of infection is imposed on almost a quarter of the world, due to widely distributed natural hosts, no approved specific treatment and vaccine is available till now, but research continues. Therefore, a detailed discussion of this forthcoming infection needs to be done. This review article focuses on the current scenario of the infection caused by the Nipah virus as well as emphasizes the potential for Nipah virus infection to become a global threat in the future. Further, this article provides a comprehensive review of the infection transmission, its signs and symptoms, diagnosis, and treatment methods with emphasis on prevention and control measures.
References
Giangaspero M. Nipah Virus. Trop Med Surg [Internet]. 2013;01(04). Available from: http://dx.doi.org/10.4172/2329-9088.1000129
Kulkarni DD, Tosh C, Venkatesh G, Senthil Kumar D. Nipah virus infection: current scenario. Indian J Virol [Internet]. 2013/11/07. 2013 Dec;24(3):398–408. Available from: https://pubmed.ncbi.nlm.nih.gov/24426305
OIE-Listed diseases 2020: OIE - World Organisation for Animal Health [Internet]. [cited 2023 Aug 21]. Available from: https://www.oie.int/en/animal-health-in-the-world/oie-listed-diseases-2020/
Clayton BA. Nipah virus: transmission of a zoonotic paramyxovirus. Curr Opin Virol [Internet]. 2017;22:97–104. Available from: http://dx.doi.org/10.1016/j.coviro.2016.12.003
Chua KB, Goh KJ, Wong KT, Kamarulzaman A, Tan PSK, Ksiazek TG, et al. Fatal encephalitis due to Nipah virus among pig-farmers in Malaysia. Lancet [Internet]. 1999;354(9186):1257–9. Available from: http://dx.doi.org/10.1016/s0140-6736(99)04299-3
Outbreak of Hendra-Like Virus -- Malaysia and Singapore, 1998-1999 [Internet]. [cited 2023 Aug 21]. Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/00056866.htm
Field H (ed. ., Daniels P (ed. ., Bee Lee O (ed. ., Jamaludin A (ed. ., Bunning M (ed. . Manual on the diagnosis of Nipah virus infection in animals. RAP Publ [Internet]. 2002 [cited 2023 Aug 21]; Available from: https://agris.fao.org/agris-search/search.do?recordID=XF2008434987
Olson JG, Rupprecht C, Rollin PE, An US, Niezgoda M, Clemins T, et al. Antibodies to Nipah-like virus in bats (Pteropus lylei), Cambodia. Emerg Infect Dis [Internet]. 2002 Sep;8(9):987–8. Available from: https://pubmed.ncbi.nlm.nih.gov/12194780
Chong HT, Abdullah S, Tan CT. Nipah virus and bats [Internet]. Vol. 14, Neurology Asia. 2009 [cited 2023 Aug 21]. Available from: http://www.who.int/csr/disease/nipah/en/index.html
Calisher CH, Childs JE, Field HE, Holmes K V, Schountz T. Bats: important reservoir hosts of emerging viruses. Clin Microbiol Rev [Internet]. 2006 Jul;19(3):531–45. Available from: https://pubmed.ncbi.nlm.nih.gov/16847084
Who, Searo, n.d. Fact Sheet - Nipah Virus Infection. [Internet]. [cited 2023 Aug 21]. Available from: http://origin.searo.who.int/entity/emerging_diseases/links/CDS_Nipah_Virus.pdf
Wacharapluesadee S, Lumlertdacha B, Boongird K, Wanghongsa S, Chanhome L, Rollin P, et al. Bat Nipah virus, Thailand. Emerg Infect Dis [Internet]. 2005 Dec;11(12):1949–51. Available from: https://pubmed.ncbi.nlm.nih.gov/16485487
Iehlé C, Razafitrimo G, Razainirina J, Andriaholinirina N, Goodman SM, Faure C, et al. Henipavirus and Tioman virus antibodies in pteropodid bats, Madagascar. Emerg Infect Dis [Internet]. 2007 Jan;13(1):159–61. Available from: https://pubmed.ncbi.nlm.nih.gov/17370536
Epstein JH, Prakash V, Smith CS, Daszak P, McLaughlin AB, Meehan G, et al. Henipavirus infection in fruit bats (Pteropus giganteus), India. Emerg Infect Dis [Internet]. 2008 Aug;14(8):1309–11. Available from: https://pubmed.ncbi.nlm.nih.gov/18680665
Hsu VP, Hossain MJ, Parashar UD, Ali MM, Ksiazek TG, Kuzmin I, et al. Nipah virus encephalitis reemergence, Bangladesh. Emerg Infect Dis [Internet]. 2004 Dec;10(12):2082–7. Available from: https://pubmed.ncbi.nlm.nih.gov/15663842
Hayman DTS, Suu-Ire R, Breed AC, McEachern JA, Wang L, Wood JLN, et al. Evidence of henipavirus infection in West African fruit bats. PLoS One [Internet]. 2008 Jul 23;3(7):e2739–e2739. Available from: https://pubmed.ncbi.nlm.nih.gov/18648649
Reynes J-M, Counor D, Ong S, Faure C, Seng V, Molia S, et al. Nipah virus in Lyle’s flying foxes, Cambodia. Emerg Infect Dis [Internet]. 2005 Jul;11(7):1042–7. Available from: https://pubmed.ncbi.nlm.nih.gov/16022778
Li Y, Wang J, Hickey AC, Zhang Y, Li Y, Wu Y, et al. Antibodies to Nipah or Nipah-like viruses in bats, China. Emerg Infect Dis [Internet]. 2008 Dec;14(12):1974–6. Available from: https://pubmed.ncbi.nlm.nih.gov/19046545
McCormack JG, Allworth AM. Emerging viral infections in Australia. Med J Aust [Internet]. 2002;177(1):45–9. Available from: http://dx.doi.org/10.5694/j.1326-5377.2002.tb04637.x
Mackenzie JS. Emerging viral diseases: an Australian perspective. Emerg Infect Dis [Internet]. 1999;5(1):1–8. Available from: https://pubmed.ncbi.nlm.nih.gov/10081666
Sendow I, Field HE, Curran J, Darminto, Morrissy C, Meehan G, et al. Henipavirus in Pteropus vampyrus bats, Indonesia. Emerg Infect Dis [Internet]. 2006 Apr;12(4):711–2. Available from: https://pubmed.ncbi.nlm.nih.gov/16715584
Morbidity and mortality due to Nipah or Nipah-like virus encephalitis in WHO South-East Asia Region, 2001-2018 [Internet]. [cited 2023 Aug 21]. Available from: https://www.google.com/search?q=Morbidity+and+mortality+due+to+Nipah+or+Nipah-like+virus+encephalitis+in+WHO+South-East+Asia+Region%2C+2001-2018&oq=Morbidity+and+mortality+due+to+Nipah+or+Nipah-like+virus+encephalitis+in+WHO+South-East+Asia+Region%2C+2001
World Health Organization, Outbreak of Nipah virus encephalitis in Kerala state of India [Internet]. [cited 2023 Aug 21]. Available from: http://origin.searo.who.int/entity/emerging_diseases/links/nipah_virus/en/
World Health Organization, Nipah virus outbreaks in the WHO South-East Asia Region [Internet]. [cited 2023 Aug 21]. Available from: http://origin.searo.who.int/entity/emerging_diseases/links/nipah_virus_outbreaks_sear/en/
WHO | Nipah virus – India [Internet]. [cited 2023 Aug 21]. Available from: https://www.who.int/csr/don/07-august-2018-nipah-virus-india/en/
Sudeep AB, Yadav PD, Gokhale MD, Balasubramanian R, Gupta N, Shete A, et al. Detection of Nipah virus in Pteropus medius in 2019 outbreak from Ernakulam district, Kerala, India. BMC Infect Dis [Internet]. 2021 Dec 1 [cited 2023 Nov 11];21(1):1–7. Available from: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-05865-7
WHO | Nipah virus disease - India [Internet]. 2021 [cited 2023 Nov 11]. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/nipah-virus-disease---india
WHO | Nipah virus disease - India [Internet]. 2023 [cited 2023 Dec 11]. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON490
Chua KB. Nipah virus outbreak in Malaysia. J Clin Virol [Internet]. 2003;26(3):265–75. Available from: http://dx.doi.org/10.1016/s1386-6532(02)00268-8
Singh RK, Dhama K, Chakraborty S, Tiwari R, Natesan S, Khandia R, Munjal A, Vora KS, Latheef SK, Karthik K, Singh Malik Y, Singh R, Chaicumpa W, Mourya DT. Nipah virus: epidemiology, pathology, immunobiology and advances in diagnosis, vaccine designing and control strategies - a comprehensive review. Vet Q. 2019 Dec;39(1):26-55. Available from: https://doi.org/10.1080/01652176.2019.1580827.
Ryu WS. Virus Life Cycle. Molecular Virology of Human Pathogenic Viruses [Internet]. 2017 May 6;31–45. Available from: https://doi.org/10.1016/B978-0-12-800838-6.00003-5
Escaffre O, Borisevich V, Rockx B. Pathogenesis of Hendra and Nipah virus infection in humans. J Infect Dev Ctries [Internet]. 2013;7(04):308–11. Available from: http://dx.doi.org/10.3855/jidc.3648
World Organisation for Animal Hhealth Manual of Diagnostic tests and vaccines for Terrestrial Animals (mammals, birds and bees) Seventh Edition Volume 2 2012 [Internet]. [cited 2023 Aug 21]. Available from: www.oie.int
Treatment Guidelines for Kerala: Nipah Virus Disease :: National Centre for Disease Control (NCDC) [Internet]. [cited 2023 Aug 21]. Available from: https://ncdc.gov.in/index1.php?lang=1&level=3&sublinkid=274&lid=242
Satterfield BA, Dawes BE, Milligan GN. Status of vaccine research and development of vaccines for Nipah virus. Vaccine [Internet]. 2016;34(26):2971–5. Available from: http://dx.doi.org/10.1016/j.vaccine.2015.12.075
Broder CC, Weir DL, Reid PA. Hendra virus and Nipah virus animal vaccines. Vaccine [Internet]. 2016/05/04. 2016 Jun 24;34(30):3525–34. Available from: https://pubmed.ncbi.nlm.nih.gov/27154393
Bossart KN, Geisbert TW, Feldmann H, Zhu Z, Feldmann F, Geisbert JB, et al. A neutralizing human monoclonal antibody protects african green monkeys from hendra virus challenge. Sci Transl Med [Internet]. 2011 Oct 19;3(105):105ra103-105ra103. Available from: https://pubmed.ncbi.nlm.nih.gov/22013123
Dawes B, Kalveram B, Ikegami T, reports TJ-S, 2018 undefined. Favipiravir (T-705) protects against Nipah virus infection in the hamster model. nature.com [Internet]. [cited 2023 Aug 21]; Available from: https://www.nature.com/articles/s41598-018-25780-3
Hendra virus requirements for horses [Internet]. [cited 2023 Aug 21]. Available from: https://www.mpi.govt.nz/dmsdocument/2844/send
CEPI Awards $25 Million Contract to Profectus BioSciences and Emergent BioSolutions to Develop Nipah Virus Vaccine – CEPI [Internet]. [cited 2023 Aug 21]. Available from: https://cepi.net/news_cepi/cepi-awards-25-million-contract-to-profectus-biosciences-and-emergent-biosolutions-to-develop-nipah-virus-vaccine/
Geisbert TW, Bobb K, Borisevich V, Geisbert JB, Agans KN, Cross RW, et al. A single dose investigational subunit vaccine for human use against Nipah virus and Hendra virus. NPJ Vaccines [Internet]. 2021 Dec 1 [cited 2023 Nov 11];6(1). Available from: /pmc/articles/PMC7870971/