Pharmacological properties and phytoconstituents of garlic (Allium sativum L.): A review

Authors

  • Sunvej Choudhary Department of Pharmacy, Quantum School of Health Sciences, Quantum University, Roorkee, Uttarakhand, 247662, India.
  • Mohd Ubed Noor Department of Pharmacy, Quantum School of Health Sciences, Quantum University, Roorkee, Uttarakhand, 247662, India.
  • Md Sadique Hussain School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, 302017, India. https://orcid.org/0000-0002-3554-1750
  • Mudita Mishra Department of Pharmacy, Quantum School of Health Sciences, Quantum University, Roorkee, Uttarakhand, 247662, India.
  • Swati Tyagi Department of Pharmacy, Quantum School of Health Sciences, Quantum University, Roorkee, Uttarakhand, 247662, India.

DOI:

https://doi.org/10.55006/biolsciences.2022.2402

Keywords:

Allium sativum, Allicin, Allin, Alzheimer disease, Cardiovascular disease

Abstract

Medicinal plants have been used since ancient times for human healthcare in the form of traditional medicines, spices, and other food components. Throughout history, many different cultures have recognized the potential use of garlic for the prevention and treatment of different diseases. Garlic is a common bulb vegetable or spice that is used as an herb and to flavor food. The plant contains biologically active components that contribute to its pharmacological properties. The medicinal effects of garlic were known for 5,000 years. Garlic is recommended as a nutritive element in the treatment of various health problems and the prolongation of human life. The chemical constituents of garlic have also been investigated for the treatment of aging, Alzheimer’s disease, anti-fungal/bacterial/viral/ Protozoans, atherosclerosis, blood pressure, cancer, cardiovascular disease, diabetes, neuro/ nephroprotection, osteoporosis, stress, hyperlipidemia, and, wound healing and highly praised by several authors. Therefore, this paper is reviewed to inspire and impress young researchers about the medicinal values of garlic.

Downloads

Download data is not yet available.

References

Prajapati, M. R., Manav, A., Singh, J., Kumar, P., Kumar, A., Kumar, R., & Baranwal, V. K. (2022). Identification and Characterization of a Garlic Virus E Genome in Garlic (Allium sativum L.) Using High-Throughput Sequencing from India. Plants, 11(2), 224.

Armentia, A., Martín-Armentia, S., Pineda, F., Martín-Armentia, B., Castro, M., Fernández, S., & Castillo, M. (2020). Allergic hypersensitivity to garlic and onion in children and adults. Allergologia et immunopathologia, 48(3), 232-236.

Marsic, N. K., Necemer, M., Veberic, R., Ulrih, N. P., & Skrt, M. (2019). Effect of cultivar and fertilization on garlic yield and allicin content in bulbs at harvest and during storage. Turkish Journal of Agriculture and Forestry, 43(4), 414-429.

Satyal, P., Craft, J. D., Dosoky, N. S., & Setzer, W. N. (2017). The chemical compositions of the volatile oils of garlic (Allium sativum) and wild garlic (Allium vineale). Foods, 6(8), 63.

Abdelrahman, M., Hirata, S., Mukae, T., Yamada, T., Sawada, Y., El-Syaed, M., … & Shigyo, M. (2021). Comprehensive metabolite profiling in genetic resources of garlic (Allium sativum L.) collected from different geographical regions. Molecules, 26(5), 1415.

Hussain, M. S., Singh, M., Kumar, B., Tewari, D., Mansoor, S., & Ganesh, N. (2020). Antimicrobial activity in ethanolic extracts of Bixa orellana L., Simarouba glauca DC, and Ocimum tenuiflorum L. collected from JNCH herbal garden. World Journal of Pharmaceutical Research, 9(4), 650-663.

Shakya, S. R., & Shakya, S. (2017). MEDICINAL USES OF GARLIC (Allium sativum L.) IN HUMAN HEALTH. The Journal of University Grants Commission, 6(1), 159-168.

Ankri, S., & Mirelman, D. (1999). Antimicrobial properties of allicin from garlic. Microbes and infection, 1(2), 125-129.

Fufa, B. K. (2019). Anti-bacterial and anti-fungal properties of garlic extract (Allium sativum): A review. Microbiol. Res. J. Int, 28, 1-5.

TIWARY, S., & HUSSAIN, M. S. (2021). Functional foods for prevention and treatment of cancer. Asian J Pharm Clin Res, 14(3), 4-10.

M. M. Rahman, V. Fazlic and N. W. Saad. (2012). Antioxidant properties of raw garlic (Allium sativum) extract; International Food Research Journal, 19(2), 589-591.

Eja, M. E., Asikong, B. E., Abriba, C., Arikpo, G. E., Anwan, E. E., & Enyi-Idoh, K. H. (2007). A comparative assessment of the antimicrobial effects of garlic (Allium sativum) and antibiotics on diarrheagenic organisms. Southeast Asian journal of tropical medicine and public health, 38(2), 343.

Bhandari, P. R. (2012). Garlic (Allium sativum L.): A review of potential therapeutic applications. International Journal of Green Pharmacy, 6(2).

Hayat, S., Ahmad, H., Ali, M., Hayat, K., Khan, M. A., & Cheng, Z. (2018). Aqueous garlic extract as a plant biostimulant enhances physiology, improves crop quality and metabolite abundance, and primes the defense responses of receiver plants. Applied Sciences, 8(9), 1505.

Shahbazi, Y. (2019). Active Polyvinylpyrrolidone Enriched with Garlic Extract. Journal of Nutrition, Fasting, and Health, 7(4 (Spe), 190-196.

Banerjee, S. K., Mukherjee, P. K., & Maulik, S. K. (2003). Garlic as an antioxidant: the good, the bad, and the ugly. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 17(2), 97-106.

V.P. Londhe, A. T. Gavasane, S. S. Nipate, D. D. Bandawane, P. D. Chaudhari. (2011). Role of garlic (ALLIUM SATIVUM) in various diseases; Journal of Pharmaceutical Research And Opinion 1: 4, 129 – 134.

Kaur, G., Hussain, M. S., & Mohit, K. T. (2021). A review of acute or chronic renal failure, common kidney diseases, and herbal plants used for management. Int J Bot Stud, 6, 50-56.

Najman, K., Sadowska, A., Buczak, K., Leontowicz, H., & Leontowicz, M. (2022). Effect of heat-treated garlic (Allium sativum L.) on growth parameters, plasma lipid profile and histological changes in the ileum of atherogenic rats. Nutrients, 14(2), 336.

Iciek, M., Kwiecień, I., & Włodek, L. (2009). Biological properties of garlic and garlic‐derived organosulfur compounds. Environmental and molecular mutagenesis, 50(3), 247-265.

Shinde Akanksha, Dond Shubhodika, Diwate Vrishali, Pawar Sonali, Katkar Rushikeshand Darandale Supriya. (2020). Historical approach of garlic(Allium sativum) in food, spices and its phytochemicals and therapeutic uses in medicine: A review; World Journal of Pharmaceutical Research, 10(01): 737-744.

Saddique, H., Hussain, F., & Shahid, M. (2015). Some biological perspectives of Allium sativum: A review. Int J Chem Biochem Sci, 8, 35-9.

So, T. K. A., Abdou, R., Sani, I. S., Toudou, A. K., & Bakasso, Y. (2021). Garlic (Allium sativum L.): Overview on its biology and genetic markers available for the analysis of its diversity in West Africa. Asian Journal of Biochemistry, Genetics, and Molecular Biology, 7(3), 1-10.

Mann, L. (1952). Anatomy of the garlic bulb and factors affecting bulb development. Hilgardia, 21(8), 195-251.

Aslam T, Mohapatra PP, Karthik CS, Das SP, Dudi BS. (2016). Characterization of Garlic (Allium Sativum L.) Genotypes Based On Morphological Characters Inter J of Agri Sci; ISSN: 0975-3710&E-ISSN: 0975-9107, 44(8).

Ipgri, E. C. P., & GR, A. (2001). Descriptors for Allium (Allium spp.). International Plant Genetic Resources Institute, Rome, Italy, 6.

Boukeria S. (2017). Etude de l’effet de la variabilité Génétique de l’espèce Allium cepa L. et Allium sativum L. sur la production et L’accumulation des huiles essentielles et Sur leurs effets antibactériens. Thèse Pour L’obtention du Diplôme de docteur en Sciences Biologiques de l’Université 8 Mai 1945 de Guelma. French. ;237.

Nasir, A., Fatma, G., Neshat, N., & Ahmad, M. A. (2020). Pharmacological and therapeutic attributes of garlic (Allium sativum Linn.) with special reference to Unani medicine—A review. J. Med. Plants Stud, 8, 6-9.

El, F., HASIB, A., BOUILLI, A., BOUSSADA, L., & ABIDI, O. (2021). Phytochemical compounds and Pharmacological Activities of Garlic (Allium sativum L.): A Review. Moroccan Journal of Public Health, 3(2), 47-64.

Hussain, M. S., Sharma, G. N., Sharma, R., Kaur, G., Kataria, T. (2022). Effect of Nutraceuticals as Therapeutic Moderators and its Impact in Economical Trade. Acta Scientific Microbiology, 5(4), 70-80.

Gore, G. G., Satish, S., Ganpule, A., Srivastava, S., & Athavale, M. (2021). Garlic (Allium sativum) exhibits anticancer and anticancer stem cell activity on breast, prostate, colon, hepatic and cervical cancer cell lines. Int J Herbal Med, 9, 93-99.

Singh, V., & Kumar, R. (2017). Study of phytochemical analysis and antioxidant activity of Allium sativum of Bundelkhand region. International Journal of Life-Sciences Scientific Research, 3(6), 1451-1458.

Rana, S. V., Pal, R., Vaiphei, K., Sharma, S. K., & Ola, R. P. (2011). Garlic in health and disease. Nutrition research reviews, 24(1), 60-71.

Deresse, D. (2010). Antibacterial effect of garlic (Allium sativum) on Staphylococcus aureus: An in vitro study. Asian J Med Sci, 2(2), 62-5.

Shang, A., Cao, S. Y., Xu, X. Y., Gan, R. Y., Tang, G. Y., Corke, H., … & Li, H. B. (2019). Bioactive compounds and biological functions of garlic (Allium sativum L.). Foods, 8(7), 246.

Patiño-Morales, C. C., Jaime-Cruz, R., Sánchez-Gómez, C., Corona, J. C., Hernández-Cruz, E. Y., Kalinova-Jelezova, I., … & Salazar-García, M. (2021). Antitumor effects of natural compounds derived from Allium sativum on neuroblastoma: an overview. Antioxidants, 11(1), 48.

Afzaal, M., Saeed, F., Rasheed, R., Hussain, M., Aamir, M., Hussain, S., … & Anjum, F. M. (2021). Nutritional, biological, and therapeutic properties of black garlic: a critical review. International Journal of Food Properties, 24(1), 1387-1402.

Halimah, L. S., Nawangsih, E. N., & Hasan K. (2021). Analysis of Antibacterial and Antioxidant Activities of a Single Bulb of Garlic Fermented into Black Garlic; Advances in Health Sciences Research, volume 37.

Abderrahim, L. A., Taïbi, K., Abderrahim, N. A., Boussaid, M., Rios-Navarro, C., & Ruiz-Saurí, A. (2019). Euphorbia honey and garlic: Biological activity and burn wound recovery. Burns, 45(7), 1695-1706.

R. B. Saudagar and V. R. (2018). Waghulde; Review on uses of garlic extract; World Journal of Pharmaceutical Research; 7(9):370-384.

Bhandari, P. R. (2012). Garlic (Allium sativum L.): A review of potential therapeutic applications. International Journal of Green Pharmacy (IJGP), 6(2).

Singh, D. K., & Singh, V. K. (2008). Pharmacological Effects of Allium Sativum L.(Garlic. Annual Review of Biomedical Sciences, 10, 6-26.

Alam, M. K., Nyeem, M., & Samad, M. A. (2018). Effects of garlic on hyperlipidemia: A review. Journal of Medicinal Plants, 6(2), 44-48.

Bathaei, F. S., & Akhondzadeh, S. (2008). Cardiovascular effects of allium sativum (garlic): an evidence-based review. The Journal of Tehran University Heart Center, 3(1), 5-10.

Paudel, K. R. (2014). Pharmacological effects of traditional herbal plant garlic (Allium sativum): A review. Journal of Kathmandu Medical College, 3(4), 158-161.

Borlinghaus, J., Foerster, J., Kappler, U., Antelmann, H., Noll, U., Gruhlke, M. C., & Slusarenko, A. J. (2021). Allicin, the odor of freshly crushed garlic: a review of recent progress in understanding allicin’s effects on cells. Molecules, 26(6), 1505.

Singh, R., & Singh, K. (2019). Garlic: A spice with wide medicinal actions. Journal of Pharmacognosy and Phytochemistry, 8(1), 1349-1355.

Alam, A., Al Arif Jahan, A., Bari, M. S., Khandokar, L., Mahmud, M. H., Junaid, M., … & Haque, M. A. (2022). Allium vegetables: Traditional uses, phytoconstituents, and beneficial effects in inflammation and cancer. Critical Reviews in Food Science and Nutrition, 1-35.

Nasir, A., Fatma, G., Neshat, N., & Ahmad, M. A. (2020). Pharmacological and therapeutic attributes of garlic (Allium sativum Linn.) with special reference to Unani medicine—A review. J. Med. Plants Stud, 8(3), 6-9.

Hussein, H. J., Hameed, I. H., & Hadi, M. Y. (2017). A Review: Anti-microbial, Anti-inflammatory effect and Cardiovascular effects of Garlic: Allium sativum. Research Journal of Pharmacy and Technology, 10(11), 4069-4078.

Singh, R. N., Kumar, P., & Kumar, N. (2018). Anti-carcinogenic activity of garlic (Allium sativum). Shodh Drishti Int Peer Rev Ref Res J, 9, 6-2.

Srivastava, KC,* Bordia, A. &Verma, S. (1995). Garlic (Allium sativum) for disease prevention. South African journal of science, 91(2), 68-77.

Palani, S., Joseph, N. M., Tegene, Y., & Zacharia, A. (2014). Medicinal Properties of Garlic–A Concise Review. Current Research in Pharmaceutical Sciences, 4,(04): 92-98.

Kamel, A., & Saleh, M. (2000). Recent studies on the chemistry and biological activities of the organosulfur compounds of garlic (Allium sativum). Studies in natural products chemistry, 23, 455-485.

Fufa, B. K. (2019). Anti-bacterial and anti-fungal properties of garlic extract (Allium sativum): A review. Microbiol. Res. J. Int, 28, 1-5.

Airaodion, A. I., Ngwogu, A. C., Ngwogu, K. O., Ekenjoku, J. A., & Megwas, A. U. (2020). Pharmacotherapeutic activity of Allium sativum (garlic) bulb against gram-positive and gram-negative bacteria. Asian J Res Infect Dis, 3(3), 22-7.

El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H., A. Al-Sagan, A., Abd El-Hack, M. E., … & Prasad Devkota, H. (2020). Chemical constituents and pharmacological activities of garlic (Allium sativum L.): A review. Nutrients, 12(3), 872.

Obi, G. C., Lawanson, A. A., & Akinlade, O. O. (2020). Potentials of Garlic as a Feed additive and Alternative to Antibiotics in poultry Production, A Review; Proceedings of 25th Annual Conference of ASAN 2020, Abuja, Nigeria (76-78).

Harris, J. C., Cottrell, S. L., Plummer, S., & Lloyd, D. (2001). Antimicrobial properties of Allium sativum (garlic). Applied microbiology and biotechnology, 57(3), 282-286.

Sharifi-Rad, J., Cristina Cirone Silva, N., Jantwal, A., D Bhatt, I., Sharopov, F., C Cho, W., … & Martins, N. (2019). Therapeutic potential of allicin-rich garlic preparations: emphasis on clinical evidence toward upcoming drugs formulation. Applied Sciences, 9(24), 5555.

Downloads

Published

25-12-2022
CITATION

How to Cite

Choudhary, S., Noor, M. U., Hussain, M. S., Mishra, M., & Tyagi, S. (2022). Pharmacological properties and phytoconstituents of garlic (Allium sativum L.): A review. Biological Sciences, 2(4), 338–346. https://doi.org/10.55006/biolsciences.2022.2402