Special issue Open call for papers
2026

Beyond the Microbiome: Microbial Signalling, Extracellular Vesicles, and Cross-Kingdom Communication in Health and Disease

Published Open call for papers Submission deadline
Guest Editors

Call for Papers – Special Issue

Biological Sciences, an international peer-reviewed journal published by IR Research Publication, invites submissions for the special issue "Beyond the Microbiome: Microbial Signalling, Extracellular Vesicles, and Cross-Kingdom Communication in Health and Disease."

Microorganisms interact with host organisms and other members of biological communities through complex molecular signalling networks involving metabolites, proteins, nucleic acids, and extracellular vesicles. These communication pathways influence immune responses, cellular homeostasis, microbial community dynamics, and disease progression.

This special issue aims to bring together high-quality original research and scholarly reviews exploring the molecular mechanisms and biological significance of microbial signalling, extracellular vesicle-mediated communication, and cross-kingdom interactions.

Submissions addressing bacteria, fungi, viruses, plants, animals, and human systems are welcome, with particular emphasis on mechanistic investigations, innovative methodologies, translational applications, and emerging therapeutic opportunities.

Guest Editors

  • Dr. Rahul Kumar Datta, Barasat Government College, Kolkata, India

  • Dr. Kalyan Mahapatra, Barasat Government College, India

All manuscripts must comply with the author guidelines of Biological Sciences and undergo independent peer review. Acceptance decisions will be based on originality, scientific rigor, methodological quality, and relevance to the special issue.

Submitting to a Special Issue

Authors must prepare and submit their manuscripts through the online submission portal, select the appropriate special issue or conference proceedings collection under the “For the Editors” step, and clearly mention the collection title in their cover letter; for detailed submission requirements, please refer to the Author Guidelines.

Open call for papers — accepting submissions

No articles have been published in this issue yet. Accepted papers will appear here as a full table of contents, exactly like a regular issue.

Submit to this issue

About this Special Issue

Aims & scope

This special issue aims to advance understanding of the molecular mechanisms, ecological significance, and biomedical applications of microbial communication across biological systems.

The collection focuses on how microorganisms communicate with host cells and other organisms through microbial metabolites, quorum-sensing molecules, extracellular vesicles, proteins, and nucleic acids. Particular attention will be given to the role of these signalling mechanisms in regulating immune responses, host physiology, microbial community organization, inflammation, and disease progression.

The scope includes extracellular vesicle biogenesis and cargo composition, microbial signalling pathways, cross-kingdom molecular interactions, host–microbiome relationships, microbial communication in infectious and noncommunicable diseases, and the development of extracellular vesicle-based diagnostic and therapeutic strategies.

Studies integrating molecular biology, microbiology, immunology, ecology, multi-omics, computational modelling, and translational medicine are particularly encouraged.

The special issue welcomes rigorous experimental investigations, interdisciplinary research, and comprehensive scholarly reviews that contribute new mechanistic insights or critically evaluate emerging developments in microbial communication.

Topics of interest

  • Microbial Signalling and Quorum-Sensing Mechanisms
  • Extracellular Vesicle Biogenesis and Molecular Cargo
  • Bacterial and Fungal Extracellular Vesicles
  • Host–Microbiome Molecular Communication
  • Cross-Kingdom Signalling in Plants, Animals, and Humans
  • Microbial Metabolites and Immune Regulation
  • Microbial Communication in Inflammation and Infectious Diseases
  • Microbiome–Cancer and Microbiome–Metabolism Interactions
  • Gut–Brain Axis and Microbial Signalling
  • Extracellular Vesicles as Diagnostic Biomarkers
  • Engineered Vesicles and Microbiome-Based Therapeutics
  • Multi-Omics Analysis of Microbial Communication
  • Microbial Community Dynamics and Host–Microbe Interactions
  • Artificial Intelligence and Computational Modelling in Microbiome Research

Manuscript types accepted

  • Original Research Article
  • Review Article
Submission deadline
Article processing charge
Manuscripts accepted for publication in this special issue will receive a full (100%) APC waiver