Solubility Enhancement of a Model Drug Quercetin by Nanotechnology Based Formulation Approach

Bashayer Alsofyani; Reem Sari Alayli; Maram Sari Alayli; Teaf Salah Alkhaldi; Ghadi Hammad Altalhi; Mohammad Akhlaquer Rahman

doi:10.55006/biolsciences.2023.3402

Authors

Bashayer Alsofyani College of Pharmacy, Taif University, Haweiya, Taif-21974, Kingdom of Saudi Arabia
Reem Sari Alayli College of Pharmacy, Taif University, Haweiya, Taif-21974, Kingdom of Saudi Arabia
Maram Sari Alayli College of Pharmacy, Taif University, Haweiya, Taif-21974, Kingdom of Saudi Arabia
Teaf Salah Alkhaldi College of Pharmacy, Taif University, Haweiya, Taif-21974, Kingdom of Saudi Arabia
Ghadi Hammad Altalhi College of Pharmacy, Taif University, Haweiya, Taif-21974, Kingdom of Saudi Arabia
Mohammad Akhlaquer Rahman College of Pharmacy, Taif University, Haweiya, Taif-21974, Kingdom of Saudi Arabia https://orcid.org/0000-0003-1073-7279

DOI:

https://doi.org/10.55006/biolsciences.2023.3402

Keywords:

Solid lipid nanoparticles, Solubility, Quercetin, Encapsulation, Bioavailability, Stability

Abstract

Approximately, 40% of drug candidates have poor water solubility and its oral delivery is frequently associated with implications of low bioavailability, hepatic first-pass metabolism, enzymatic degradation, high intra- and inter subject variability, and lack of dose proportionality. Interests in solid lipid nanoparticles (SLN) to improve the oral bioavailability of such drugs (PWSD) are well known and documented in the literature. The aim of the research is to prepare solid lipid nanoparticles of quercetin by emulsification-ultrasonication method and evaluate the optimized formulation for solubility enhancement. Different batches of SLNs were prepared by emulsification-ultrasonication methods by changing process parameters, and finally on the basis of nanoparticle size, polydispersity index (PDI), zeta potential (ZP), encapsulation efficiency (EE), an optimum system was designed. The optimized formulation (Q-SLN9) demonstrated particle size, PDI, ZP, and EE; 327 nm, 0.118, 32.3 mV, and 57.9%, respectively. The optimized formulation has shown the highest zeta potential (-32.3 mV) confers its stability. In-vitro release of the drug showed significant improvement in the release of quercetin from SLN formulation as compared to plain drug. Furthermore, quercetin-loaded SLN was found to be stable at 4°C for 30 days of study period. The formulation was successfully prepared by the proposed method that can be used as a potential carrier for successful delivery of poorly water-soluble drugs associated with poor oral bioavailability.

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