Curcumin Attenuates Cytotoxic Effect of Bisphenol A in the Liver of Adult Wister Rats

Sunday Okon Elijah; Moses Ibrahim Auza; Abigail Abraham; Charles O. Ayara

doi:10.55006/biolsciences.2024.4210

Authors

Sunday Okon Elijah Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine and Allied health Sciences, Bingham University, Karu, Nasarawa State https://orcid.org/0000-0003-3739-304X
Moses Ibrahim Auza Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine and Allied health Sciences, Bingham University, Karu, Nasarawa State https://orcid.org/0000-0002-8830-6471
Abigail Abraham Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine and Allied health Sciences, Bingham University, Karu, Nasarawa State
Charles O. Ayara Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine and Allied health Sciences, Bingham University, Karu, Nasarawa State

DOI:

https://doi.org/10.55006/biolsciences.2024.4210

Keywords:

Bisphenol A, Cytotoxic, Liver, Curcumin, Wistar Rats

Abstract

This study investigates the effect of curcumin on bisphenol A induced cytotoxicity in the liver of adult Wister rats. Twenty adult Wistar rats (weight = 190±10g) were placed into four groups (N=4). Group 1 (control) received vital feed, water and sunflower oil only throughout the research, group 2 (BPA) received vital feed, water and 65mg/kg of bisphenol A, group 3 (BPA and Curcumin) received vital feed, water and 65ml/kg of bisphenol A and 100mg/kg of Curcumin, and group 4 (Curcumin) received vital feed, water and 100mg/kg of curcumin for a total 28 days. Rats exposed to BPA for 28 days demonstrated liver damages as evidence by increased concentration of Alkaline phosphatase (ALP) in blood, increase in Malondialdehyde (MDA) concentration and decrease in Glutathione (GSH) level. In regard to histological analysis, curcumin had positive effects on the liver except for group 2 (BPA) which showed degenerative changes due to the administration of bisphenol A only. This study reveals that curcumin has ameliorative and cytoprotective effect on bisphenol A cytotoxocity on the liver.

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