Review on nanogel/emulgel formulations of traditional medicines

Authors

  • Surbhi Gupta Department of Pharmaceutics, Nirmala Devi Pharmacy College Nayansand Gaurabadshahpur, Jaunpur, Uttar Pradesh 222133, India
  • Janhavi Gupta Sri Harish Chandra Postgraduate College, Institute of Pharmacy, Varanasi, Uttar Pradesh 221002, India
  • Anubhav Anand Hygia Institute of Pharmaceutical Education and Research, Lucknow, Uttar Pradesh, 226020, India
  • Smriti Ojha Department of Pharmaceutical Science and Technology, Madan Mohan Malaviya University of Technology, Gorakhpur, Uttar Pradesh, India

DOI:

https://doi.org/10.55006/biolsciences.2022.2304

Keywords:

Herbal, Nanogel, Nanoemulgel, Nanotechnology, Traditional medicine

Abstract

Nanotechnology is being ventured into as an emerging trend eliciting improvements in nearly all technological fields, and the pharmaceutical sector is no exception to this. It has been used for many years for synthetic drugs. But nowadays, the focus is on traditional medicines. This work is focused on the nanogel and nanoemulgel formulations of traditional medication and holds strong relevance in the emerging era of nanomedicine. Herbal medicines are making a resurgence in the twenty-first century, as the dangers and limitations of modern medicine become increasingly evident, and herbal remedies are considered a balanced and reasonable approach to treatment. Advances in analysis and clinical research demonstrate the efficacy of herbal drugs in disease prevention and treatment. The main issue with herbal remedies is their inability to dissolve and stabilize. New technical breakthroughs have the potential to eliminate the problems connected with herbal therapy.Nanoformulations reflect the interface between new technology and herboceuticals. Thus nanosized novel drug delivery system of herbal drugs has a potential future due to their high drug encapsulation capacity, homogeneity, low toxicity, and improved stability.

This article is a part of Special Issue "Advances in the field of Nanomedicine"

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References

Ali MI, Dayma J, Moin S. Nanoparticles for the Enhancement of the Therapeutic Efficacy of Herbal Formulations. In Enhancing the Therapeutic Efficacy of Herbal Formulations 2021 (pp. 149-172). IGI Global.

Das S, Sharangi AB. Nanotechnology: A Potential Tool in Exploring Herbal Benefits. InFunctional Bionanomaterials 2020 (pp. 27-46). Springer, Cham.

Hub, pharma wisdom. "a review on herbal nanoparticles." 2020 Jul 16

Dongare PN, Motule AS, Dubey MR, More MP, Patinge PA, Bakal RL, Manwar JV. Recent development in novel drug delivery systems for delivery of herbal drugs: An updates. GSC Advanced Research and Reviews. 2021;8(2):008-18.

Dhiman A, Nanda A, Ahmad S. Novel herbal drug delivery system (NHDDS): the need of hour. InInternational Conference on Environment, Chemistry and Biology 2012 (Vol. 49, pp. 171-175).

Sindhu RK, Gupta R, Wadhera G, Kumar P. Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications. Gels. 2022 Feb 7;8(2):97.

Jain S, Jain A, Jain V, Kohli D. New perspectives on herbal nanomedicine. Handbook of Polymers for Pharmaceutical Technologies. 2015 Jun 29:215.

Dongare PN, Motule AS, Dubey MR, More MP, Patinge PA, Bakal RL, Manwar JV. Recent development in novel drug delivery systems for delivery of herbal drugs: An updates. GSC Advanced Research and Reviews. 2021;8(2):008-18.

Patil RY, Patil SA, Chivate ND, Patil YN. Herbal drug nanoparticles: Advancements in herbal treatment. Research J. Pharm. and Tech. 2018 Jan 31;11(1):421-6.

Chaudhari PM, Paithankar AV. Herbal nanogel formulation: a novel approch. Science and Technology. 2020 Sep;5(05).

Divya G, Panonnummal R, Gupta S, Jayakumar R, Sabitha M. Acitretin and aloe-emodin loaded chitin nanogel for the treatment of psoriasis. European Journal of Pharmaceutics and Biopharmaceutics. 2016 Oct 1;107:97-109.

Sindhu RK, Gupta R, Wadhera G, Kumar P. Modern Herbal Nanogels: Formulation, Delivery Methods, and Applications. Gels. 2022 Feb 7;8(2):97.

Raut BP, Khan SA, Ubhate AA, Ganjiwale RO. A review on herbal nanoemulgel for the treatment of acne vulgaris. World Journal of Pharmaceutical Research. 2021 May 27; 10(9):487-497.

Chandra A, Arya RK, Pal GR, Tewari B. Formulation and evaluation of ginger extract loaded nanoemulgel for the treatment of rheumatoid arthritis. Journal of Drug Delivery and Therapeutics. 2019 Jul 20;9(4):559-70.

Hewlings SJ, Kalman DS. Curcumin: A Review of Its’ Effects on Human Health. Foods [Internet]. 2017 Oct 1 [cited 2022 May 19];6(10). Available from: /pmc/articles/PMC5664031/

Javed H, Shah SNH, Iqbal FM. Formulation Development and Evaluation of Diphenhydramine Nasal Nano-Emulgel. AAPS PharmSciTech [Internet]. 2018/03/24. 2018;19(4):1730–43. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29569155

Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clinical and Experimental Pharmacology and Physiology. 2012 Mar;39(3):283–99.

Sarika PR, James NR, Raj DK. Preparation, characterization and biological evaluation of curcumin loaded alginate aldehyde–gelatin nanogels. Materials Science and Engineering: C. 2016 Nov 1;68:251-7.

Algahtani MS, Ahmad MZ, Nourein IH, Albarqi HA, Alyami HS, Alyami MH, Alqahtani AA, Alasiri A, Algahtani TS, Mohammed AA, Ahmad J. Preparation and characterization of curcumin nanoemulgel utilizing ultrasonication technique for wound healing: In vitro, ex vivo, and in vivo evaluation. Gels. 2021 Dec;7(4):213

Desu PK, Karmakar B, Kondi V, Tiwari ON, Halder G. Optimizing formulation of green tea extract-loaded chitosan nanogel. Biomass Conversion and Biorefinery [Internet]. 2022 Feb 15 [cited 2022 May 19];1–14. Available from: https://link.springer.com/article/10.1007/s13399-022-02453-w.

Piran F, Khoshkhoo Z, Hosseini SE, Azizi MH. Controlling the antioxidant activity of green tea extract through encapsulation in chitosan-citrate nanogel. Journal of Food Quality. 2020 Jul 3;2020.

. Mao QQ, Xu XY, Cao SY, Gan RY, Corke H, Beta T, Li HB. Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods. 2019 May 30;8(6):185.

Chandra A, Arya RK, Pal GR, Tewari B. Formulation and evaluation of ginger extract loaded nanoemulgel for the treatment of rheumatoid arthritis. Journal of Drug Delivery and Therapeutics. 2019 Jul 20;9(4):559-70.

Okpalaku O, Uronnachi E, Okoye E, Umeyor C, Nwakile C, Okeke T, Attama A. Evaluating some Essential Oils-Based and Coconut Oil Nanoemulgels for the Management of Rheumatoid Arthritis.

Nergiz C, Ă–tleĹź S. Chemical composition of Nigella sativa L. seeds. Food chemistry. 1993 Jan 1;48(3):259-61.

Sultan MH, Javed S, Madkhali OA, Alam MI, Almoshari Y, Bakkari MA, Sivadasan D, Salawi A, Jabeen A, Ahsan W. Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach. Molecules. 2022 Mar 9;27(6):1796.

Algahtani MS, Ahmad MZ, Shaikh IA, Abdel-Wahab BA, Nourein IH, Ahmad J. Thymoquinone Loaded Topical Nanoemulgel for Wound Healing: Formulation Design and In-Vivo Evaluation. Molecules. 2021 Jan;26(13):3863.

Naik JB, Rajput RL, Narkhede JS, Mujumdar A, Patil PB. Synthesis and evaluation of UV cross-linked poly (acrylamide) loaded thymol nanogel for antifungal application in oral candidiasis. Journal of Polymer Research. 2021 Jan;28(1):1-3.

Ahmad J, Gautam A, Komath S, Bano M, Garg A, Jain K. Topical nano-emulgel for skin disorders: Formulation approach and characterization. Recent patents on anti-infective drug discovery. 2019 May 1;14(1):36-48.

Chen R, Qi QL, Wang MT, Li QY. Therapeutic potential of naringin: an overview. Pharmaceutical biology. 2016 Dec 1;54(12):3203-10.

Yusof S, Ghazali HM, King GS. Naringin content in local citrus fruits. Food Chemistry. 1990 Jan 1;37(2):113-21.

Ahmed S, Khan H, Aschner M, Hasan MM, Hassan ST. Therapeutic potential of naringin in neurological disorders. Food and Chemical Toxicology. 2019 Oct 1;132:110646.

Nagaraja S, Basavarajappa GM, Karnati RK, Bakir EM, Pund S. Ion-Triggered In Situ Gelling Nanoemulgel as a Platform for Nose-to-Brain Delivery of Small Lipophilic Molecules. Pharmaceutics. 2021 Aug;13(8):1216.

Yeo E, Chieng CJ, Choudhury H, Pandey M, Gorain B. Tocotrienols-rich naringenin nanoemulgel for the management of diabetic wound: Fabrication, characterization and comparative in vitro evaluations. Current Research in Pharmacology and Drug Discovery. 2021 Jan 1;2:100019.

Mulia K, Ramadhan RM, Krisanti EA. Formulation and characterization of nanoemulgel mangosteen extract in virgin coconut oil for topical formulation. InMATEC Web of Conferences 2018 (Vol. 156, p. 01013). EDP Sciences.

Astuti KW, Wijayanti NP, Yustiantara PS, Laksana KP, Putra PS. Anti-inflammatory activity of mangosteen (Garcinia Mangostana Linn.) rind extract nanoemulgel and gel dosage forms. Biomedical and Pharmacology Journal. 2019 Dec 28;12(04):1767-74.

Wijayanti NP, Yustiantara PS, Widiantara IW. Optimization of Glyceryl Polyacrylate in Nanoemulgel of Mangosteen (Garcinia mangostana L.) Rind Fraction. Biomedical and Pharmacology Journal. 2021 Jun 30;14(2):1051-7.

Sood R, Chopra DS. Optimization of reaction conditions to fabricate Ocimum sanctum synthesized silver nanoparticles and its application to nano-gel systems for burn wounds. Materials Science and Engineering: C. 2018 Nov 1;92:575-89.

Sinha P, Srivastava S, Mishra N, Singh DK, Luqman S, Chanda D, Yadav NP. Development, optimization, and characterization of a novel tea tree oil nanogel using response surface methodology. Drug development and industrial pharmacy. 2016 Sep 1;42(9):1434-45.

Eid AM, Issa L, Al-Kharouf O, Jaber R, Hreash F. Development of Coriandrum sativum Oil Nanoemulgel and Evaluation of Its Antimicrobial and Anticancer Activity. BioMed Research International. 2021 Oct 11; 2021.

Suryawanshi JS, Gawade SP. Enhanced anti-arthritic effect of mustard oil in Nanoemulgel Formulation: A comparative clinical study. Research Journal of Pharmacy and Technology. 2020 Aug 12;13(8):3738-44.

Bakr RO, Zaghloul SS, Amer RI, Mostafa DA, El Bishbishy MH. Formulation, Characterization and Antimicrobial efficacy of Aegle marmelos Essential oil nanogel. Research Journal of Pharmacy and Technology. 2021 Jul 19;14(7):3662-8.

Eid AM, Hawash M. Biological evaluation of Safrole oil and Safrole oil Nanoemulgel as antioxidant, antidiabetic, antibacterial, antifungal and anticancer. BMC Complementary Medicine and Therapies. 2021 Dec;21(1):1-2.

Ting TC, Rahim NF, Zaudin NA, Abdullah NH, Mohamad M, Shoparwe NF, Ramle SF, Aimi Z, Hamid ZA, Yusof AH. Development and Characterization of Nanoemulgel Containing Piper betle Essential Oil as Active Ingredient. InIOP Conference Series: Earth and Environmental Science 2020 Dec 1 (Vol. 596, No. 1, p. 012032). IOP Publishing.

Eid AM, El-Enshasy HA, Aziz R, Elmarzugi NA. Preparation, characterization and anti-inflammatory activity of Swietenia macrophylla nanoemulgel. J Nanomed Nanotechnol. 2014 Mar 1;5(2):1-0

Kumar S, Singh KK, Rao R. Enhanced anti-psoriatic efficacy and regulation of oxidative stress of a novel topical babchi oil (Psoralea corylifolia) cyclodextrin-based nanogel in a mouse tail model. Journal of microencapsulation. 2019 Feb 17;36(2):140-55.

Almeida KB, Araujo JL, Cavalcanti JF, Romanos MT, MourĂŁo SC, Amaral AC, FalcĂŁo DQ. In vitro release and anti-herpetic activity of Cymbopogon citratus volatile oil-loaded nanogel. Revista Brasileira de Farmacognosia. 2018 Jul;28:495-502

Paul S, Dhinakaran I, Mathiyazhagan K, Raja M, Sasikumar CS, Varghese JC. Preparation of nanogel incorporated with silver nanoparticles synthesized from pongamiapinnata. L root. Int J Sci Res Knowl. 2015;3(12):0314-25.

Ojha S, & Kumar B. A review on nanotechnology based innovations in diagnosis and treatment of multiple sclerosis. J Cell Immunother. 2018; 4(2): 56-64.

Ojha S, & Kumar B. Preparation and statistical modeling of solid lipid nanoparticles of dimethyl fumarate for better management of multiple sclerosis. Adv Pharm bull. 2018; 8(2): 225.

Anand A, Arya M, Kaithwas G, Singh G, & Saraf SA. Sucrose stearate as a biosurfactant for development of rivastigmine containing nanostructured lipid carriers and assessment of its activity against dementia in C. elegans model. J Drug Deliv Sci Technol 2019;49:219-226.

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Published

29-07-2022
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How to Cite

Gupta, S., Gupta, J., Anand, A. ., & Ojha, S. (2022). Review on nanogel/emulgel formulations of traditional medicines. Biological Sciences, 2(3), 269–278. https://doi.org/10.55006/biolsciences.2022.2304