Development and Evaluation of Resveratrol Loaded Modified Oleic Acid Based Vesicles for the Treatment of UV-B Induced Precancerous Skin Lesions

Abstract

Skin cancer is associated with the abnormal growth of skin cells; it most often develops on skin exposed to the sun. The conventional treatment such as cream, gel, etc. are less flexible, so they don’t penetrate deep into the skin (dermal layer), it remains at the upper part of the skin (epidermal layer). Stratum corneum acts as a physiological barrier for the drug-loaded in cream and gel. An oleic acid-based vesicle is used to deliver the bioactive Resveratrol into the skin to overcome the stratum corneum. The scope of the current study is to develop Resveratrol-loaded oleic acid vesicles, which are used to enhance the permeability of drugs into the deeper layers of the skin and overcoming the stratum corneum barrier. The proposed study claims that it can retain the permeated bioactive into the deeper layer for a longer duration to get the sustained effect of the drug in the dermal region and avoid the systemic exposure and toxicity of the drug. Resveratrol-loaded oleic acid vesicles would be a promising approach for the topical delivery of drugs/bioactive for the treatment of UV-B-induced precancerous skin lesions.

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