Development and Evaluation of Polyherbal Formulation for Anti Diabetic Potential in Streptozotocin-Induced Diabetic Rats
Department of Pharmacology, School of Pharmaceutical Sciences and Technology Sardar Bhagwan Singh University, Dehradun, Uttarakhand 248001, India
- Received
- Published
Abstract
Diabetes is the most common metabolic disorder that involves various pathogenic mechanisms and is characterized by high blood sugar levels. Genetic and environmental factors cause insufficient insulin secretion, increased glucose production, abnormal fat, or protein metabolism. Major sources of diabetes are chronic complications that started with prolonged hyperglycemia. According to ayurvedic scriptures such as Charak Samhita, polyherbal formulations have been mentioned to have anti-diabetic potentials. Thus, the present study was aimed to find the anti-diabetic effect of polyherbal formulation in rat models. Diabetes was induced by a single dose of Streptozotocin (60 mg/kg) for 72 hours. The effect of the polyherbal formulation was studied in diabetic rats for 21 days. The biochemical and anti-oxidant parameters such as fasting blood glucose, cholesterol, triglycerides, HDL, LDL, VLDL, SGOT, SGPT, Urea, Uric acid, LPO, SOD, and GSH were measured during the study. The polyherbal formulation produced a significant reduction of fasting blood glucose and lipid profile. Kidney function tests, liver function tests, and anti-oxidant parameters were also improved. Overall, after 21 days of study, the results show that the polyherbal formulation is much more effective for type 1 diabetes in rats.
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